Module Overview
Module 1: Salt, Water and Hypertension
- Basics on renal Na+, K+, Cl- and water handling and their hormonal regulation
- Impact of dietary Na+ and K+ intake on blood pressure and the aldosterone paradox
- Cellular and molecular mechanism of arterial hypertension and disturbed water balance
Module 2: Acid-base Homeostasis
- Tubular mechanism of renal handling of acids and bases
- Control of acid-base homeostasis and the respective role of the kidney, the lung and other organs
- Mechanism of renal tubular acidosis and other kidney-related disturbances in acid-base balance
Module 3: Calcium and Phosphate
- Physiology and pathophysiology of renal tubular handling of divalent cations and the involved hormonal control systems
- Pathogenesis of vascular and urinary calcifications
Module 4: Oxygen Signaling and Cancer
- General mechanism of cellular oxygen sensing
- Physiology and pathophysiology of renal erythropoietin production
- VHL disease and clear cell renal cell carcinoma
Module 5: Metabolism and Kidney Function
- Dietary proteins and kidney function: amino acid transport, kidney growth, nitrogen disposal and water handling
- GFR as measure of kidney function, role of age and relation to kidney volume
Module 6: Inflammation and Immunology
- Inflammation and progression of chronic kidney disease
- Direct and indirect immune-mediated renal diseases
- Immune system in kidney transplantation